{"id":6588,"date":"2014-02-25T09:25:28","date_gmt":"2014-02-25T09:25:28","guid":{"rendered":"http:\/\/www.fortunetimes.sg\/cn\/?p=6588"},"modified":"2021-08-21T15:50:19","modified_gmt":"2021-08-21T07:50:19","slug":"e7949fe789a9e588b6e88dafe78988e59d97efbc9ae696b0e7998ce79787e6b2bbe79697e68a80e69cafe68890e8b584e69cace5b882e59cbae6988ee6989f","status":"publish","type":"post","link":"https:\/\/az.c.adneti.net\/cn\/?p=6588","title":{"rendered":"\u751f\u7269\u5236\u836f\u7248\u5757\uff1a\u65b0\u764c\u75c7\u6cbb\u7597\u6280\u672f\u6210\u8d44\u672c\u5e02\u573a\u660e\u661f"},"content":{"rendered":"

\u81ea2\u6708\u4ee5\u6765\uff0c\u7f8e\u56fd\u751f\u7269\u5236\u836f\u754c\u6380\u8d77\u4e86\u4e00\u80a1IPO\u72c2\u6f6e\uff0c\u603b\u5171\u67098\u5bb6\u521b\u65b0\u578b\u516c\u53f8\u643a\u5e26\u7740\u672a\u7ecf\u5145\u5206\u4e34\u5e8a\u9a8c\u8bc1\u7684\u6280\u672f\u5728\u8d44\u672c\u5e02\u573a\u4e0a\u5174\u98ce\u4f5c\u6d6a\uff0c\u4ec5\u4ec5\u4e0a\u5468\uff0c\u751f\u7269\u5236\u836f\u516c\u53f8\u7ecfIPO\u878d\u8d44\u89c4\u6a21\u5c31\u5df2\u7ecf\u8fbe\u5230\u4e865\u4ebf\u7f8e\u5143\u5de6\u53f3\u3002\u5355\u5c31\u7eb3\u65af\u8fbe\u514b\u5e02\u573a\u6765\u770b\uff0c\u5728\u8fc7\u53bb\u4e00\u5e74\u4e2d\uff0c\u751f\u7269\u5236\u836f\u7248\u5757\u7684\u80a1\u4ef7\u98d9\u5347\u4e86\u4e09\u5206\u4e4b\u4e8c\u5de6\u53f3\u3002<\/p>\n

\n\t\u3000\u3000\u751f\u7269\u5236\u836f\u7248\u5757\u662f“\u9ec4\u91d1”\u8fd8\u662f“\u5e9f\u94c1”\uff1f<\/strong><\/p>\n

\n\t\u3000\u3000\u4e50\u89c2\u578b\u6295\u8d44\u8005\u6307\u51fa\uff0c\u751f\u7269\u5236\u836f\u7248\u5757\u5728\u5168\u7403\u540e\u91d1\u878d\u5371\u673a\u65f6\u4ee3\u6210\u4e3a\u65b0\u7684\u6295\u8d44\u70ed\u70b9\uff0c\u53cd\u6620\u51fa\u4eba\u7c7b\u5065\u5eb7\u9886\u57df\u4e2d\u65b0\u601d\u8def\u3001\u65b0\u6280\u672f\u3001\u65b0\u89c2\u5ff5\u7684\u4e0d\u65ad\u878d\u5408\u8fdb\u5316\u7684\u5927\u80cc\u666f\u3002\u751f\u7269\u5236\u836f\u5de5\u7a0b\u6280\u672f\u96be\u5ea6\u5927\uff0c\u4e13\u5229\u95e8\u69db\u9ad8\uff0c\u9762\u5bf9\u5168\u7403\u4e0d\u65ad\u8001\u9f84\u5316\u4eba\u53e3\u4ee5\u53ca\u8fc5\u731b\u589e\u957f\u7684\u5065\u5eb7\u9700\u6c42\uff0c\u8fd9\u4e2a\u9886\u57df\u5c06\u6210\u4e3a\u771f\u6b63\u7684“\u9ec4\u91d1\u7248\u5757”\u3002<\/p>\n

\n\t\u3000\u3000\u4f46\u60b2\u89c2\u6027\u6295\u8d44\u8005\u8ba4\u4e3a\uff0c\u751f\u7269\u5236\u836f\u5de5\u7a0b\u79d1\u6280\u5f00\u53d1\u96be\u5ea6\uff0c\u4e13\u4e1a\u4eba\u624d\u975e\u5e38\u6709\u9650\uff0c\u800c\u975e\u4e13\u4e1a\u4eba\u58eb\u53c8\u5f88\u96be\u628a\u63e1\u5f00\u53d1\u6d41\u7a0b\uff0c\u7279\u522b\u662f\u672c\u8f6e\u4e0a\u5e02\u7684\u516b\u5bb6\u751f\u7269\u5236\u836f\u516c\u53f8\uff0c\u4ed6\u4eec\u7684\u6838\u5fc3\u6280\u672f\u4ecd\u7136\u5904\u4e8e\u8bd5\u9a8c\u5ba4\u5f00\u53d1\u9636\u6bb5\uff0c\u5c1a\u672a\u5f97\u5230\u5927\u89c4\u6a21\u4e34\u5e8a\u666e\u53ca\u3002\u4f17\u6240\u5468\u77e5\uff0c\u751f\u7269\u5236\u836f\u6280\u672f\u5728\u65e9\u671f\u9636\u6bb5\u7684\u5931\u8d25\u7387\u975e\u5e38\u9ad8\u3002\u5728\u5927\u91cf\u8d44\u91d1\u6d8c\u5165\u7684\u60c5\u51b5\u4e0b\uff0c\u5f88\u53ef\u80fd\u6210\u4e3a\u5236\u836f\u516c\u53f8\u548c\u6295\u8d44\u5927\u9cc4\u5229\u7528IPO\u635e\u94b1\u7684\u5de5\u5177\u3002<\/p>\n

\n\t\u3000\u3000\u4ee5DICERNA\u516c\u53f8\u4e3a\u4f8b\uff0c\u8be5\u516c\u53f8\u4e3b\u8981\u91c7\u7528RNA\uff08\u6838\u7cd6\u6838\u9178\uff0c\u4e00\u79cd\u9057\u4f20\u4fe1\u606f\u8f7d\u4f53\uff09\u6280\u672f\u5e73\u53f0\u6cbb\u7597\u9057\u4f20\u6027\u809d\u75c5\u53ca\u764c\u75c7\u3002\u4e0a\u6708\uff0cDICERNA\u516c\u53f8\u901a\u8fc7IPO\u878d\u8d449\u5343\u4e07\u7f8e\u5143\uff0c\u5176\u80a1\u4ef7\u5728\u53d1\u884c\u7684\u7b2c\u4e00\u5929\uff0c\u5c31\u7a9c\u5347\u4e86207%\u3002\u4f46\u636e\u77e5\u60c5\u4eba\u58eb\u4ecb\u7ecd\uff0cDICERNA\u516c\u53f8\u7684\u809d\u75c5\u548c\u764c\u75c7\u6cbb\u7597\u6280\u672f\u4ecd\u7136\u5904\u4e8e\u65e9\u671f\u7814\u53d1\u9636\u6bb5\uff0c\u53ea\u6709\u7ea65%\u7684\u53ef\u80fd\u6027\u6210\u529f\u5b9e\u73b0\u7814\u53d1\u3002\u6362\u53e5\u8bdd\u8bf4\uff0c\u5982\u679c\u65b0\u836f\u5931\u8d25\uff0c\u6295\u8d44\u8005\u6301\u6709\u7684\u80a1\u7968\u5f88\u53ef\u80fd\u5728\u4e00\u591c\u4e4b\u95f4\u53d8\u4e3a\u5e9f\u7eb8\u3002<\/p>\n

\n\t\u3000\u3000\u9664DICERNA\u516c\u53f8\u5916\uff0c\u53e6\u5916\u4e09\u5bb6\u65b0\u4e0a\u5e02\u7684\u516c\u53f8\u4e5f\u5b58\u5728\u540c\u6837\u7684\u95ee\u9898\uff0c\u5982\u751f\u4ea7\u6cbb\u7597HIV\u3001\u809d\u75c5\uff08\u4e59\u809d\u3001\u4e19\u809d\uff09\u7684\u751f\u7269\u578b\u5236\u5242GILEAD\u516c\u53f8\uff1b\u6cbb\u7597\u795e\u7ecf\u6027\u75be\u75c5\u3001\u8840\u53cb\u75c5\u3001\u514d\u75ab\u7cfb\u7edf\u7d0a\u4e71\u7684BIOGEN IDEC\uff1b\u4ece\u6cbb\u7597\u80bf\u7624\u5316\u7597\u5f15\u8d77\u7684\u55dc\u4e2d\u6027\u767d\u7ec6\u80de\u51cf\u5c11\u75c7\u7684\u521b\u65b0\u578b\u836f\u7269\u8d77\u5bb6\u7684\u7f8e\u56fd\u5b89\u8fdb\u516c\u53f8\uff08AMGEN INC\uff09\u7b49\u3002<\/p>\n

\n\t\u3000\u3000\u660e\u77e5\u5c71\u6709\u864e \u504f\u5411\u864e\u5c71\u884c<\/strong><\/p>\n

\n\t\u3000\u3000\u96be\u9053\u6295\u8d44\u8005\u4e0d\u660e\u767d\u8fd9\u4e9b\u98ce\u9669\u5417\uff1f\u5931\u8d25\u7387\u5982\u6b64\u4e4b\u9ad8\u7684\u9886\u57df\u4e3a\u4f55\u80fd\u591f\u5438\u5f15\u91cd\u91d1\uff1f\u8fd9\u6050\u6015\u662f\u56e0\u4e3a\u751f\u7269\u79d1\u6280\u5728\u8d44\u672c\u5e02\u573a\u4e2d\u7684\u8bb2\u6545\u4e8b\u80fd\u529b\u53d8\u5f97\u8d8a\u6765\u8d8a\u5f3a\u3002<\/p>\n

\n\t\u3000\u3000\u7b2c\u4e00\u4e2a\u6545\u4e8b\uff1a\u5229\u7528\u57fa\u56e0\u6280\u672f\u6cbb\u7597\u9057\u4f20\u75be\u75c5<\/strong><\/p>\n

\n\t\u3000\u3000\u5982\u679c\u5bf9\u4e0a\u8ff0\u751f\u7269\u5236\u836f\u516c\u53f8\u4e0a\u5e02\u6587\u4ef6\u8fdb\u884c\u5206\u6790\uff0c\u4e0d\u96be\u53d1\u73b0\uff0c\u57fa\u56e0\u6cbb\u7597\u6280\u672f\u51e0\u4e4e\u662f\u6240\u6709\u516c\u53f8\u672a\u6765\u53d1\u5c55\u7684\u4e3b\u65b9\u5411\u3002<\/p>\n

\n\t\u3000\u3000\u6240\u8c13\u57fa\u56e0\u6cbb\u7597\u6280\u672f\uff0c\u5176\u6838\u5fc3\u6982\u5ff5\u5c31\u662f\u5728\u60a3\u8005\u751f\u75c5\u7ec4\u7ec7\u7684\u57fa\u56e0\u5185\u690d\u5165\u5065\u5eb7\u57fa\u56e0\uff0c\u4ee5\u4fee\u8865\u6216\u66ff\u4ee3\u5f15\u53d1\u75be\u75c5\u7684\u57fa\u56e0\u3002\u4e4d\u542c\u4e0a\u53bb\uff0c\u8fd9\u5c31\u8c61\u662f\u79d1\u5e7b\u5c0f\u8bf4\uff0c\u6709\u4eba\u79f0\u4e4b\u4e3a“\u4fee\u8865\u4e0a\u5e1d\u7684\u8bed\u8a00”\u3002\u5b83\u7684\u53d1\u5c55\u4e5f\u4e00\u6ce2\u4e09\u6298\u3002\u57fa\u56e0\u6cbb\u7597\u6280\u672f\u81ea\u4e0a\u4e16\u7eaa\u4e5d\u5341\u5e74\u4ee3\u5f00\u5c55\u4ee5\u6765\uff0c\u66fe\u5907\u53d7\u4e89\u8bae\uff0c\u5176\u4e2d\u6700\u53d7\u8206\u8bba\u5173\u6ce8\u7684\u662f\u4e00\u4f4d\u7f8e\u56fd\u809d\u75c5\u60a3\u8005\u57281999\u5e74\u6b7b\u4ea1\u7684\u4e8b\u4ef6\u30022003\u5e74\uff0c\u6cd5\u56fd\u4e5f\u51fa\u73b0\u4e86\u540c\u6837\u7684\u95ee\u9898\uff0c\u6570\u4f4d\u60a3\u6709SCID\u9057\u4f20\u514d\u75ab\u7f3a\u9677\u75c5\u75c7\u7684\u5b69\u5b50\uff0c\u5728\u63a5\u53d7\u57fa\u56e0\u7597\u6cd5\u4e4b\u540e\u60a3\u4e0a\u4e86\u767d\u8840\u75c5\u3002\u8fd9\u4e2a\u6848\u4f8b\u66fe\u7ecf\u5dee\u4e00\u70b9\u4f7f\u57fa\u56e0\u6cbb\u7597\u6280\u672f\u88ab\u5e9f\u6b62\u3002<\/p>\n

\n\t\u3000\u3000\u4f46\u81ea\u6b64\u4e4b\u540e\uff0c\u57fa\u56e0\u6cbb\u7597\u6280\u672f\u5f00\u59cb\u53d8\u5f97\u9010\u6e10\u7a33\u5b9a\u4e0b\u6765\u3002\u5982\u5bf9\u4e8e\u6cbb\u7597\u8102\u86cb\u767d\u5f02\u5e38\u60a3\u8005\uff08\u4e73\u7cdc\u5fae\u7c92\u8840\u75c7\uff0cChylomicronemia\u53ef\u4ee5\u5bfc\u81f4\u8840\u8102\u589e\u9ad8\uff0c\u4ece\u800c\u5f15\u53d1\u5404\u79cd\u76f8\u5173\u75be\u75c5\uff09\u975e\u5e38\u6709\u6548\uff0c\u5df2\u7ecf\u83b7\u5f97\u76f8\u5173\u76d1\u7ba1\u90e8\u95e8\u7684\u6279\u51c6\uff0c\u76ee\u524d\u5728\u6b27\u6d32\u8fdb\u5165\u4e34\u5e8a\u5e94\u7528\u4e4b\u4e2d\u3002<\/p>\n

\n\t\u3000\u3000\u4e0a\u6708\uff0c\u57fa\u56e0\u6cbb\u7597\u6280\u672f\u53d6\u5f97\u91cd\u5927\u7a81\u7834\uff0c\u636e\u300a\u67f3\u53f6\u5200\u300bLANCET\u62a5\u9053\uff0c\u725b\u6d25\u5927\u5b66\u6559\u6388\u9ea6\u514b\u62c9\u4f26\uff08Robert Maclaren\uff09\u5df2\u7ecf\u627e\u5230\u4e86\u9488\u5bf9\u773c\u79d1\u75c5\u75c7\u65e0\u8109\u7edc\u819c\uff08\u9057\u4f20\u6027\u539f\u53d1\u6027\u8109\u7edc\u819c\u53d8\u6027\uff0c\u5b66\u540d\uff1aChoroideremia\uff0c\u5b83\u662f\u4f34X\u8fde\u9501\u9690\u6027\u9057\u4f20\u6027\u514d\u75ab\u7f3a\u9677\u75be\u75c5\uff0c\u7537\u6027\u60a3\u8005\u901a\u5e38\u4ece\u5341\u5c81\u524d\u5f00\u59cb\u53d1\u75c5\u3002\u6700\u521d\u75c7\u72b6\u5e38\u4e3a\u591c\u76f2\uff0c\u4ee5\u540e\u89c6\u91ce\u53d8\u7a84\uff0c\u6700\u7ec8\u89c6\u89c9\u4e27\u5931\uff09\u7684\u6cbb\u7597\u624b\u6bb5\u3002\u8fd9\u79cd\u75be\u75c5\u662f\u7531\u4e00\u79cd\u540d\u4e3aREP1\u7684\u57fa\u56e0\u53d8\u5f02\u5f15\u8d77\u7684\uff08\u56e0REP1\u57fa\u56e0\u53d8\u5f02\uff0c\u773c\u775b\u89c6\u7f51\u819c\u4e0a\u7684\u5149\u611f\u53d7\u7ec6\u80de\u6e10\u6e10\u9000\u5316\uff09\u3002\u9ea6\u514b\u62c9\u4f26\u4f7f\u7528\u4e86\u4e00\u79cd\u7279\u6b8a\u7684\u75c5\u6bd2\u505a\u4e3a“\u4fe1\u4f7f”\uff0c\u5c06\u5065\u5eb7\u7684REP1\u57fa\u56e0\u4f20\u9012\u5230\u89c6\u7f51\u819c\u6700\u654f\u611f\u7684\u5730\u5e26\u3002\u8bd5\u9a8c\u53d6\u5f97\u4e86\u8f83\u5927\u6210\u529f\uff0c\u516d\u540d\u53c2\u4e0e\u8bd5\u9a8c\u7684\u60a3\u8005\u4e2d\uff0c\u6709\u4e94\u4eba\u773c\u775b\u5bf9\u5149\u654f\u611f\u5ea6\u5f97\u5230\u589e\u52a0\u3002\u5176\u4e2d\u4e24\u4eba\u7684\u89c6\u529b\u6062\u590d\u6700\u4e3a\u660e\u663e\uff0c\u60a3\u8005\u751a\u81f3\u53ef\u4ee5\u4ece\u89c6\u529b\u8868\u8bfb\u51fa\u66f4\u591a\u7684\u5b57\u6bcd\u3002<\/p>\n

\n\t\u3000\u3000\u9ea6\u514b\u62c9\u4f26\u53d6\u5f97\u7684\u7a81\u7834\u662f\u5efa\u7acb\u5728\u53e6\u5916\u4e24\u540d\u9057\u4f20\u57fa\u56e0\u6cbb\u7597\u4e13\u5bb6\u7684\u6210\u679c\u4e4b\u4e0a\u3002\u6b64\u524d\uff0c\u5bbe\u897f\u6cd5\u5c3c\u4e9a\u5927\u5b66\u6559\u6388\u9ea6\u594e\u5c14\uff08Albert Maguire\uff09\u548c\u8d1d\u5185\u7279\uff08Jean Bennett\uff09\u66fe\u4f7f\u7528\u7c7b\u4f3c\u6280\u672f\u6cbb\u7597\u8fc7\u53e6\u5916\u4e00\u79cd\u5148\u5929\u6027\u773c\u79d1\u75c5\u75c7—\u83b1\u4f2f\u5148\u5929\u6027\u9ed1\u6726\uff08\u5b66\u540d\uff1aLeber congenital amaurosis\uff09\uff0c\u5b83\u7684\u8d77\u56e0\u662f\u4e00\u79cd\u540d\u4e3aRPE65\u7684\u57fa\u56e0\u53d8\u5f02\u3002\u7531\u4e8e\u7f3a\u4e4f\u8fd9\u79cd\u57fa\u56e0\uff0c\u89c6\u7f51\u819c\u7ec6\u80de\u65e0\u6cd5\u6b63\u5e38\u5438\u6536\u7ef4\u751f\u7d20A\uff0c\u4ece\u800c\u6700\u7ec8\u5bfc\u81f4\u5931\u660e\u3002\u540c\u6837\uff0c\u5982\u679c\u5c06\u6b63\u5e38\u7684RPE65\u57fa\u56e0\u901a\u8fc7“\u75c5\u6bd2\u4fe1\u4f7f”\u62f7\u8d1d\u5230\u89c6\u7f51\u819c\u4e0a\uff0c\u4f1a\u4f7f\u60a3\u8005\u7684\u773c\u775b\u5bf9\u5149\u7ebf\u66f4\u52a0\u654f\u611f\uff0c\u751a\u81f3\u4f1a\u63d0\u9ad8\u89c6\u529b\u3002<\/p>\n

\n\t\u3000\u3000\u9ea6\u514b\u62c9\u4f26\u3001\u9ea6\u594e\u5c14\u548c\u672c\u5185\u7279\u91c7\u7528\u7684“\u75c5\u6bd2\u4fe1\u4f7f“\u662f\u4e00\u79cd\u817a\u4f34\u968f\u75c5\u6bd2\uff08Adeno-associated viruses\uff09\uff0c\u5b83\u4e0d\u4f1a\u5f15\u53d1\u75be\u75c5\u7684\u75c5\u6bd2\uff0c\u5f53\u7136\u4e5f\u4e0d\u4f1a\u523a\u6fc0\u514d\u75ab\u7cfb\u7edf\uff09\u3002\u4e0d\u8fc7\uff0c\u6765\u81ea\u7c73\u5170\u7684\u5723\u62c9\u83f2\u5c14\u52df\u6350\u57fa\u56e0\u6cbb\u7597\u7814\u7a76\u6240\uff08San Raffaele Telethon\uff09\u7684\u7eb3\u5c14\u7b2c\u5c3c\u535a\u58eb\uff08Luigi Naldini\uff09\u6240\u4f7f\u7528\u7684\u65b9\u6cd5\u5c31\u5f88\u5413\u4eba\u4e86—\u4ed6\u91c7\u7528\u7684\u662f\u4eceHIV\u75c5\u6bd2\u4e2d\u5206\u79bb\u51fa\u6765\u7684“\u4fe1\u4f7f”\u6765\u626e\u6f14\u4f20\u9012\u89d2\u8272\u3002\u4f17\u6240\u5468\u77e5\uff0cHIV\u662f\u5f15\u53d1\u827e\u6ecb\u75c5\u611f\u67d3\u7684\u7f6a\u9b41\u7978\u9996\u3002<\/p>\n

\n\t\u3000\u3000\u7eb3\u5c14\u7b2c\u5c3c\u4f7f\u7528\u521b\u65b0\u4e2d\u548c\u6280\u672f\uff0c\u4f7fHIV\u75c5\u6bd2”\u6539\u90aa\u5f52\u6b63”\uff0c\u6210\u4e3a\u643a\u5e26\u5065\u5eb7\u57fa\u56e0\u7684“\u4fe1\u4f7f”\u3002\u4e4b\u540e\uff0c\u8fd9\u4f4d“\u4fe1\u4f7f”\u88ab\u6ce8\u5165\u5230\u7f3a\u4e4f\u5065\u5eb7\u57fa\u56e0\u7684\u9020\u8840\u5e72\u7ec6\u80de\u4e4b\u4e2d\uff0c\u4ee5\u6cbb\u7597\u963b\u788d\u795e\u7ecf\u53d1\u80b2\u7684\u5f02\u67d3\u6027\u8111\u767d\u8d28\u75c5\u53d8\uff08metachromatic leukodystrophy\uff09\u548c\u7ef4\u65af\u79d1\u7279-\u5965\u5c14\u5fb7\u91cc\u5947\u7efc\u5408\u5f81\uff08Wiskott-Aldrich syndrome\u5373\u4f34\u6e7f\u75b9\u548c\u8840\u5c0f\u677f\u6dd8\u6c70\u7684\u514d\u75ab\u7f3a\u9677\u75c5\uff09\u3002\u7ecf\u57fa\u56e0\u6cbb\u7597\u4e4b\u540e\uff0c\u5c11\u6570\u75c5\u4eba\u7684\u75c5\u75c7\u51cf\u7f13\uff0c\u75db\u82e6\u5f97\u5230\u4e86\u51cf\u8f7b\u3002<\/p>\n

\n\t\u3000\u3000\u867d\u7136\u5230\u76ee\u524d\u4e3a\u6b62\uff0c\u57fa\u56e0\u6cbb\u7597\u624b\u6bb5\u90fd\u662f\u9488\u5bf9\u4e0a\u8ff0\u8fd9\u4e9b\u7f55\u89c1\u75c5\u75c7\u5b9e\u65bd\u7684\uff0c\u5b83\u7684\u6548\u679c\u4ecd\u7136\u5728\u89c2\u6d4b\u4e4b\u4e2d\uff0c\u4f46\u662f\uff0c\u8fd9\u79cd\u601d\u8def\u5bf9\u4e8e\u6cbb\u7597\u66f4\u5e38\u89c1\u7684\u75be\u75c5\u5177\u6709\u6781\u5927\u7684\u501f\u9274\u4f5c\u7528\uff0c\u7279\u522b\u662f\u5bf9\u4e8e\u6cbb\u7597\u4eba\u7c7b\u7684\u4e16\u7eaa\u987d\u75c7—\u764c\u75c7\u3002<\/p>\n

\n\t\u3000\u3000\u7b2c\u4e8c\u4e2a\u6545\u4e8b\uff1a\u5229\u7528\u57fa\u56e0\u6280\u672f\u6cbb\u7597\u764c\u75c7<\/strong><\/p>\n

\n\t\u3000\u3000\u5728\u4f7f\u7528\u57fa\u56e0\u6280\u672f\u6cbb\u7597\u764c\u75c7\u9886\u57df\u4e2d\uff0c\u7ebd\u7ea6\u7eaa\u5ff5\u65af\u9686\u51ef\u7279\u7433\u764c\u75c7\u4e2d\u5fc3\uff08Memorial Sloan-Kettering Cancer Center\uff09\u6559\u6388\u8428\u5fb7\u6797\uff08Michel Sadelain\uff09\u662f\u4e1a\u754c\u516c\u8ba4\u7684\u9876\u5c16\u4e13\u5bb6\u3002\u4ed6\u7684\u7814\u7a76\u51fa\u53d1\u70b9\u662f\u5d4c\u5408\u6297\u539f\u53d7\u4f53\uff08Chimeric antigen receptor\uff09\uff0c\u8fd9\u662f\u4e00\u79cd\u7ecf\u8fc7\u52a0\u5de5\u540e\u7684T\u7ec6\u80de\u3002T\u7ec6\u80de\u662f\u6dcb\u5df4\u7ec6\u80de\u7684\u4e00\u79cd\uff0c\u4e5f\u662f\u4eba\u4f53\u514d\u75ab\u7cfb\u7edf\u7684\u91cd\u8981\u7ec4\u6210\u90e8\u5206\uff0c\u53ef\u4ee5\u6740\u6b7b\u80bf\u7624\u7ec6\u80de\u3002\u6709\u5a92\u4f53\u66fe\u6307\u51fa\uff0c\u5982\u679c\u8428\u5fb7\u6797\u6559\u6388\u7684\u7814\u7a76\u6700\u7ec8\u80fd\u591f\u6210\u529f\uff0c\u90a3\u4e48\u4eba\u7c7b\u672a\u6765\u5c31\u53ef\u4ee5\u50cf\u6cbb\u6108\u611f\u5192\u822c\u6cbb\u7597\u764c\u75c7\u3002<\/p>\n

\n\t\u3000\u3000\u8428\u5fb7\u6797\u6559\u6388\u4ece\u60a3\u6709\u767d\u8840\u75c5\u548c\u6dcb\u5df4\u764c\u7684\u75c5\u4eba\u4f53\u5185\u63d0\u53d6\u51fa\u81ea\u7136\u7684T\u7ec6\u80de\uff0c\u4e4b\u540e\u52a0\u5165\u65b0\u7684\u57fa\u56e0\u3002\u8fd9\u79cd\u65b0\u57fa\u56e0\u53d6\u6e90\u4e8e\u5355\u514b\u9686\u6297\u4f53\uff0c\u5b83\u4eec\u4e4b\u6240\u4ee5\u88ab\u9009\u51fa\u7528\u4e8e\u6cbb\u7597\uff0c\u662f\u56e0\u4e8e\u5b83\u4eec\u81ea\u8eab\u4e0e\u6240\u9700\u6cbb\u7597\u764c\u75c7\u5177\u6709“\u59fb\u4eb2”\u7684\u5173\u7cfb\u3002\u91cd\u7ec4\u540e\uff0cT\u7ec6\u80de\u5bf9\u764c\u75c7\u7ec6\u80de\u7684\u6ce8\u610f\u529b\u88ab\u5524\u9192\uff0c\u8fd9\u4f7f\u5f97T\u7ec6\u80de\u53d8\u5f97\u6709\u653b\u51fb\u6027\uff0c\u80fd\u591f\u5b8c\u6210\u5bfb\u627e\u3001\u53d1\u73b0\u5e76\u50ac\u6bc1\u764c\u7ec6\u80de\u7684\u4efb\u52a1\u3002\u4e4b\u540e\uff0c\u88ab\u91cd\u7ec4\u6539\u826f\u7684T\u7ec6\u80de\u518d\u91cd\u65b0\u6ce8\u56de\u5230\u75c5\u4eba\u7684\u4f53\u5185\uff0c\u5e76\u5728\u60a3\u8005\u7684\u8eab\u4f53\u88ab\u6fc0\u6d3b\uff0c\u4ece\u800c\u4e0d\u65ad\u590d\u5236\u5e76\u5b8c\u6210\u81ea\u7136\u7e41\u6b96\u8fc7\u7a0b\uff0c\u6700\u7ec8\u80fd\u591f\u6709\u9488\u5730\u6027\u7684\u653b\u51fb\u764c\u7ec6\u80de\u3002\u6362\u53e5\u8bdd\u8bf4\uff0cT\u7ec6\u80de\u5b9e\u9645\u4e0a\u5c31\u626e\u6f14\u4e86\u4e00\u6b3e\u65b0\u578b\u6d3b\u6027\u836f\u7269\u89d2\u8272\u3002<\/p>\n

\n\t\u3000\u3000\u53bb\u5e74\uff0c\u8428\u5fb7\u6797\u535a\u58eb\u548c\u5bbe\u897f\u6cd5\u5c3c\u4e9a\u5927\u5b66\u4e00\u540d\u7814\u7a76\u56e2\u961f\u8d1f\u8d23\u4eba\u6731\u6069\uff08Carl June\uff09\u5408\u4f5c\u53d1\u8868\u4e86\u6587\u7ae0\uff0c\u9610\u8ff0\u4e86\u5229\u7528\u5d4c\u5408\u6297\u539f\u53d7\u4f53\u6cbb\u7597\u6025\u6027\u6dcb\u5df4\u7ec6\u80de\u6027\u767d\u8840\u75c5\u7684\u53ef\u884c\u6027\u3002\u4ed6\u4eec\u5728\u6587\u7ae0\u4e2d\u6307\u51fa\uff0c\u4e94\u4f4d\u53c2\u4e0e\u8bd5\u9a8c\u7684\u75c5\u4eba\u75c5\u60c5\u7f13\u89e3\u7a0b\u5ea6\u975e\u5e38\u660e\u663e\u3002\u800c\u6731\u6069\u535a\u58eb\u7684\u56e2\u961f\u5219\u5229\u7528\u57fa\u56e0\u6cbb\u7597\u65b9\u6cd5\u5b8c\u5168\u6cbb\u6108\u4e86\u4e24\u540d\u767d\u8840\u75c5\u513f\u7ae5\u3002\u5728\u53bb\u5e7412\u6708\u8fdb\u884c\u7684\u7f8e\u56fd\u8840\u6db2\u75c5\u5b66\u4f1a\u5e74\u4f1a\u4e0a\uff0c\u4e24\u4f4d\u7814\u7a76\u8005\u5206\u522b\u5c31\u4ed6\u4eec\u7684\u8fdb\u5c55\u505a\u51fa\u4e86\u8be6\u7ec6\u7684\u62a5\u544a\u3002<\/p>\n

\n\t\u3000\u3000\u9664\u4e86\u4e0a\u8ff0\u8fd9\u79cd\u8f83\u4e3a\u901a\u7528\u7684\u624b\u6bb5\uff0c\u5982\u5728\u7279\u5b9a\u7684\u67d3\u75c5\u7ec4\u7ec7\u7ec6\u80de\u4e2d\u52a0\u5165\u57fa\u56e0\u7247\u65ad\uff0c\u4f7f\u4e4b\u589e\u52a0\u65b0\u7684\u529f\u80fd\uff0c\u4ece\u5185\u90e8\u5bf9\u6297\u764c\u75c7\u5916\uff1b\u53e6\u5916\u4e00\u79cd\u9006\u5411\u601d\u8def\u4e5f\u547c\u4e4b\u6b32\u51fa\uff0c\u8fd9\u4e2a\u624b\u6bb5\u5219\u662f\u7f16\u8f91\u5df2\u7ecf\u5b58\u5728\u7684\u764c\u75c7\u57fa\u56e0\uff0c\u5373\u6253\u788e\u539f\u6709\u7684\u7ec4\u5408\uff0c\u4f7f\u4e4b\u6210\u4e3a\u6cbb\u7597\u764c\u75c7\u7684\u65b0\u624b\u6bb5\u3002\u6362\u53e5\u8bdd\u8bf4\uff0c\u4ee5\u5f80\u7684\u624b\u6bb5\u662f\u901a\u8fc7\u4fc3\u4f7f\u5065\u5eb7\u57fa\u56e0\u53d8\u5f02\uff0c\u4f7f\u4e4b\u6210\u4e3a\u5f3a\u5927\u7684“\u6b66\u58eb”\uff0c\u6740\u6b7b\u764c\u75c7\u7ec6\u80de\u3002\u800c\u65b0\u601d\u8def\u5219\u662f\u4fee\u6539\u7f16\u8f91\u5df2\u77e5\u7684\u764c\u75c7\u7ec6\u80de\uff0c\u6539\u53d8\u5df2\u7ecf\u53d8\u5f02\u57fa\u56e0\u7684\u5e8f\u5217\uff0c\u5728\u764c\u7ec6\u80de\u5185\u90e8\u5236\u9020\u9ebb\u70e6\uff0c\u4f7f\u5b83\u4eec\u81ea\u8eab\u4ea7\u751f\u57fa\u56e0\u53d8\u5f02\uff0c\u6700\u7ec8\u56e0\u65e0\u6cd5\u7e41\u6b96\u800c\u6b7b\u53bb\u3002\u800c\u652f\u6301\u8fd9\u79cd\u601d\u8def\u7684\u6280\u672f\u53eb“CRISPR-Cas9\u7f16\u8f91“\uff0c\u5b83\u7684\u6838\u5fc3\u6784\u67b6\u662f\u91c7\u7528\u81ea\u7136\u7684\u75c5\u6bd2\u6297\u4f53\u7c89\u788e\u57fa\u56e0\uff0c\u4ece\u800c\u8fdb\u884c\u7cbe\u786e\u7f16\u8f91\u3002<\/p>\n

\n\t\u3000\u3000\u5b9e\u73b0\u8fd9\u4e2a\u601d\u8def\u7684\u6280\u672f\u975e\u5e38\u5927\uff0c\u56e0\u4e3a\u8981\u60f3\u4e86\u89e3\u764c\u7ec6\u80de\uff0c\u5fc5\u987b\u8981\u5728\u4eba\u5de5\u73af\u5883\u4e2d\u5408\u6210\u764c\u7ec6\u80de\u57fa\u56e0\u3002\u5728\u8fd9\u4e2a\u9886\u57df\u4e2d\uff0c\u4e2d\u56fd\u5df2\u7ecf\u8d70\u5230\u4e86\u9886\u5148\u7684\u4f4d\u7f6e\u3002\u5357\u4eac\u533b\u79d1\u5927\u5b66\u6559\u6388\u6c99\u5bb6\u8c6a\u5728\u4eca\u5e741\u670830\u65e5\u7684\u300a\u7ec6\u80de\u300b\uff08CELL\uff09\u6742\u5fd7\u53d1\u8868\u6587\u7ae0\u6307\u51fa\uff0c\u4ed6\u4eec\u6210\u529f\u5229\u7528CPISPR-CAS9\u6280\u672f\u5bf9\u5b6a\u751f\u7684\u98df\u87f9\u7334\u8fdb\u884c\u4e86\u7cbe\u786e\u7684\u57fa\u56e0\u4fee\u9970\u3002\u8fd9\u662f\u4eba\u7c7b\u5386\u53f2\u4e0a\u9996\u6b21\u5728\u7075\u957f\u7c7b\u52a8\u7269\u4e2d\u53d6\u5f97\u7684\u7a81\u7834\u3002\u8fd9\u4e2a\u624b\u6bb5\u5bf9\u5df2\u6709\u7684\u764c\u75c7\u6cbb\u7597\u624b\u6bb5\u63d0\u51fa\u4e86\u9006\u5411\u601d\u7ef4\u7684\u65b9\u5f0f\uff0c\u4e5f\u5c31\u662f\u8bf4\uff0c\u5728\u8bb8\u591a\u79d1\u5b66\u5bb6\u8003\u8651\u5982\u4f55\u7528\u5229\u7528\u57fa\u56e0\u89e3\u51b3\u764c\u75c7\u95ee\u9898\u4e4b\u65f6\uff0c\u6c99\u6559\u6388\u5219\u521b\u9020\u590d\u5236\u51fa\u57fa\u56e0\u7f3a\u9677\u3002<\/p>\n

\n\t\u3000\u3000\u5728\u4f7f\u7528\u57fa\u56e0\u6cbb\u7597\u764c\u75c7\u7684\u7814\u7a76\u5f81\u9014\u4e0a\uff0c\u65e0\u8bba\u662f\u6b63\u5411\u6cbb\u7597\uff0c\u8fd8\u662f\u53cd\u5411\u91cd\u7ec4\uff0c\u79d1\u5b66\u5bb6\u4eec\u6700\u7ec8\u8981\u8fbe\u6210\u7684\u76ee\u6807\u5f88\u7b80\u5355\uff0c\u5373\u5b9e\u73b0\u5bf9DNA\u7f16\u7801\u8fc7\u7a0b\u7684\u91cd\u65b0\u7ec4\u5408\uff0c\u5373\u800c\u5b9e\u73b0\u5bf9\u57fa\u56e0—\u8fd9\u79cd“\u4e0a\u5e1d\u7684\u8bed\u8a00”\u6700\u7ec8\u7f16\u8f91\uff0c\u8fbe\u5230\u9020\u670d\u4eba\u7c7b\u7684\u80fd\u529b\u3002\u8fd9\u79cd\u601d\u8def\uff0c\u4e0d\u4ec5\u4ec5\u5728\u4e1a\u754c\u5f97\u5230\u8ba4\u53ef\uff0c\u540c\u65f6\u4e5f\u6e10\u6e10\u5730\u88ab\u653f\u5e9c\u673a\u6784\u627f\u8ba4\u3002\u65e9\u5728\u4e24\u5e74\u524d\uff0c\u82f1\u56fd\u4eba\u7c7b\u53d7\u7cbe\u4e0e\u80da\u80ce\u5b66\u7ba1\u7406\u5c40\u66fe\u7ecf\u53d1\u8868\u8fc7\u7c7b\u4f3c\u516c\u4f17\u77e5\u60c5\u4e66\uff0c\u8ba4\u53ef\u4e86\u4e00\u79cd\u540d\u4e3a“\u7b2c\u4e8c\u4e2a\u6bcd\u4eb2“\u7684\u6cbb\u7597\u624b\u6bb5\uff0c\u5373\u5728\u56e0\u9057\u4f20\u53d8\u5f02\u800c\u6709\u53ef\u80fd\u4ea7\u751f\u75be\u75c5\u7684\u80da\u80ce\u4e2d\u52a0\u5165\u7b2c\u4e8c\u4e2a\u6bcd\u4eb2\u7684DNA\u7247\u65ad\uff0c\u4f7f\u751f\u75c5\u7684DNA\u7247\u65ad\u4e0e\u5065\u5eb7\u7684DNA\u7247\u65ad\u4ea7\u751f\u9694\u79bb\u3002<\/p>\n

\n\t\u3000\u3000\u7b2c\u4e09\u4e2a\u6545\u4e8b\uff1a\u5728\u4eba\u4f53\u5185\u7ec4\u5efa\u5065\u5eb7\u57fa\u56e0\u519b\u56e2<\/strong><\/p>\n

\n\t\u3000\u3000\u5728\u57fa\u56e0\u5b66\u8005\u773c\u4e2d\uff0c\u4eba\u7c7b\u5728\u6f2b\u957f\u8fdb\u5316\u8fc7\u7a0b\u4e2d\u5f62\u6210\u7684\u86cb\u767d\u8d28\u57fa\u56e0\uff0c\u672c\u8eab\u5c31\u5177\u6709\u836f\u7528\u4ef7\u503c\uff0c\u5982\u679c\u4eba\u7c7b\u80fd\u591f\u4e0d\u4f9d\u9760\u5916\u529b\uff0c\u53ea\u4f9d\u9760\u6539\u53d8\u81ea\u8eab\u57fa\u56e0\u5373\u53ef\u9632\u8303\u75be\u75c5\uff0c\u90a3\u662f\u4e00\u4ef6\u975e\u5e38\u4e86\u4e0d\u8d77\u7684\u4e8b\u60c5\u3002\u56e0\u6b64\uff0c\u7ec4\u5efa“\u57fa\u56e0\u519b\u56e2”\u7684\u601d\u8def\uff0c\u5728\u65b0\u6280\u672f\u7684\u5e2e\u52a9\u4e0b\uff0c\u53d8\u5f97\u8d8a\u6765\u8d8a\u6e05\u6670\u3002<\/p>\n

\n\t\u3000\u3000\u5728\u9057\u4f20\u57fa\u56e0\u79d1\u5b66\u5bb6\u773c\u4e2d\uff0c\u4eba\u4f53\u8eab\u4f53\u7ec4\u7ec7\u4e2d\uff0c\u6700\u5177\u6d3b\u529b\uff0c\u6700\u6709\u751f\u547d\u529b\u7684\u7ec6\u80de\u662f\u5a74\u513f\u7ec6\u80de\u3002\u60f3\u50cf\u4e00\u4e0b\uff0c\u5f53\u5a74\u513f\u7684\u624b\u6307\u88ab\u5272\u4f24\u4e86\uff0c\u5982\u679c\u4f24\u53e3\u4e0d\u6df1\uff0c\u4ec5\u4ec5\u662f\u8868\u76ae\u4f24\u7684\u8bdd\uff0c\u5bf9\u4e8e\u6bcd\u4eb2\u6765\u8bf4\uff0c\u5e76\u4e0d\u662f\u4e00\u4ef6\u5f88\u53ef\u6015\u7684\u4e8b\u60c5\u3002\u4e5f\u8bb8\uff0c\u5728\u4e00\u9635\u54ed\u558a\uff0c\u6cc9\u6d8c\u822c\u7684\u6cea\u6c34\u4e4b\u540e\uff0c\u5988\u5988\u7ed9\u5a07\u5ae9\u7684\u5c0f\u6307\u5934\u4e0a\u8d34\u4e0a\u4e86\u90a6\u8fea\u521b\u53ef\u8d34\uff0c\u4e8b\u5b9e\u4e0a\uff0c\u8fd9\u5982\u540c\u4e00\u6b21\u4eea\u5f0f\uff0c\u4e00\u6b21\u6210\u957f\u7684\u5c0f\u5c0f\u6ce2\u6298\u3002\u8fc7\u4e86\u4e24\u5929\uff0c\u4f24\u53e3\u81ea\u52a8\u6108\u5408\u4e86\uff0c\u65b0\u7684\uff0c\u95ea\u95ea\u53d1\u4eae\u7684\u7c89\u7ea2\u8272\u808c\u8089\u53c8\u91cd\u65b0\u5728\u4f24\u53e3\u4e0a\u6210\u957f\u8d77\u6765\uff0c\u4f24\u75db\u6108\u5408\u4e86\u3002<\/p>\n

\n\t\u3000\u3000\u6bd4\u8d77\u6210\u4eba\u8fdf\u949d\u3001\u6f2b\u957f\u7684\u590d\u6108\u8fc7\u7a0b\uff0c\u5b69\u5b50\u7684\u808c\u80a4\u6108\u5408\u5f97\u975e\u5e38\u5feb\uff0c\u8fd9\u662f\u56e0\u4e3a\uff0c\u5a74\u513f\u7684\u7ec6\u80de\u975e\u5e38\u5e74\u8f7b\uff0c\u4ed6\u4eec\u4ee5\u6781\u5feb\u7684\u901f\u5ea6\u548c\u6781\u9ad8\u7684\u6548\u7387\u6765\u5b9e\u73b0\u5e94\u8be5\u505a\u7684\u4e8b\u60c5—\u4fee\u590d\u548c\u751f\u957f\u3002\u60f3\u50cf\u4e00\u4e0b\uff0c\u5982\u679c\u5e74\u8f7b\u7ec6\u80de\u4eec\u7ec4\u6210\u7684\u519b\u56e2\u88ab\u50a8\u5b58\u8d77\u6765\uff0c\u5f53\u4eba\u4f53\u53d7\u4f24\u6216\u662f\u5f97\u75c5\u7684\u65f6\u5019\uff0c\u533b\u5b66\u4e13\u5bb6\u80fd\u591f\u8c03\u52a8\u8fd9\u6837\u4e00\u652f\u519b\u56e2\u53bb\u4fee\u8865\u3001\u5b8c\u5584\u3001\u6cbb\u6108\uff0c \u5c06\u662f\u591a\u4e48\u4f1f\u5927\u7684\u53d1\u73b0\u3002<\/p>\n

\n\t\u3000\u3000\u8fd9\u6837\u7684\u5e74\u8f7b\u7ec6\u80de\uff0c\u5bf9\u4e8e\u6000\u5b55\u7684\u6bcd\u4eb2\u6765\u8bf4\uff0c\u662f\u5929\u8d50\u4e4b\u7269\u3002\u6b63\u56e0\u6b64\uff0c\u5e74\u8f7b\u7ec6\u80de\u4e0e\u6bcd\u4f53\u4e4b\u95f4\u7684\u5173\u7cfb\uff0c\u5df2\u7ecf\u6210\u4e3a\u6700\u65b0\u7684\u57fa\u56e0\u6cbb\u7597\u7814\u7a76\u9886\u57df\u3002\u5728\u8fd9\u4e2a\u9886\u57df\u4e4b\u4e2d\uff0c\u4e1a\u5185\u516c\u8ba4\u7684\u4ee3\u8868\u6027\u4e13\u5bb6\u662f\u5854\u592b\u8328\u5927\u5b66\u7684\u6234\u5b89\u5a1c.\u6bd4\u5b89\u5947\u535a\u58eb\u3002\u6bd4\u5b89\u5947\u535a\u58eb\u7684\u59cb\u70b9\u662f\u4e3a\u5b55\u5987\u63d0\u4f9b\u66f4\u597d\u7684\u4ea7\u524d\u68c0\u67e5\u624b\u6bb5\uff0c\u5979\u66fe\u8bd5\u56fe\u53d1\u73b0\u4e00\u79cd\u65b0\u7684\u68c0\u6d4b\u65b9\u5f0f\u6765\u66ff\u4ee3\u4fb5\u5165\u5f0f\u8bca\u65ad\u624b\u6bb5—\u7f8a\u7a7f\u3002 \u4f46\u7f8a\u7a7f\u7684\u98ce\u9669\u4e5f\u662f\u771f\u5b9e\u5b58\u5728\u7684\uff0c\u56e0\u4e3a\u5b83\u53ef\u80fd\u5bfc\u81f4\u5b55\u5987\u6d41\u4ea7\u3002<\/p>\n

\n\t\u3000\u3000\u6bd4\u5b89\u5947\u7684\u8bbe\u60f3\u662f\uff1a\u5a74\u513f\u7684\u7ec6\u80de\u5c06\u957f\u671f\u5b58\u5728\u4e8e\u6bcd\u4f53\u4e4b\u5185\uff0c\u5373\u4fbf\u662f\u5206\u5a29\u4e4b\u540e\uff08\u6216\u662f\u4e2d\u6b62\u598a\u5a20\uff09\uff0c\u4e5f\u53ef\u4ee5\u5728\u6bcd\u4f53\u4e2d\u627e\u5230\u5a74\u513f\u7684\u7ec6\u80de\uff0c\u8fd9\u79cd\u76f8\u4e92\u4f9d\u604b\u548c\u5171\u5b58\u7684\u65b9\u5f0f\u5c06\u4f1a\u4fdd\u6301\u5230\u4eba\u751f\u7684\u7ec8\u70b9\u3002\u5979\u7528\u4e00\u53e5“\u7ec8\u751f\u6000\u5b55”\u6765\u89e3\u91ca\u8fd9\u79cd\u73b0\u8c61\uff0c\u5e76\u63d0\u51fa\u4e86\u4e00\u4e2a\u4ee4\u79d1\u5b66\u5bb6\u611f\u5230\u778b\u76ee\u7ed3\u820c\u7684\u7406\u8bba\uff1a“\u5987\u5973\u5c06\u7ec8\u751f\u643a\u5e26\u6000\u5b55\u671f\u95f4\u7531\u5a74\u513f\u8d4b\u4e88\u5979\u7684\u5c0f\u5c0f\u793c\u7269\u3002”<\/p>\n

\n\t\u3000\u3000\u6bd4\u5b89\u5947\u57282004\u5e746\u67087\u65e5\u5728\u7f8e\u56fd\u533b\u5b66\u534f\u4f1a\u6708\u520a\uff08JAMA\uff09\u4e0a\u53d1\u8868\u6587\u7ae0\u8bc1\u5b9e\uff1a\u6bcd\u4f53\u4e2d\u5b58\u5728\u7684\u5a74\u513f\u7ec6\u80de\u5e76\u975e\u65e0\u7f18\u65e0\u6545\u5b58\u5728\u7684\u3002\u5b83\u4eec\u5728\u6bcd\u4eb2\u7684\u4e00\u751f\u4e2d\u626e\u6f14\u7740\u91cd\u8981\u7684\u6cbb\u6108\u89d2\u8272\u3002\u5982\u679c\u6bcd\u4f53\u53d7\u4f24\uff0c\u6216\u662f\u5728\u67d0\u4e00\u4e2a\u5668\u5b98\u4e0a\u611f\u67d3\u75be\u75c5\uff0c\u5373\u4fbf\u662f\u5728\u5b55\u4ea7\u5341\u5e74\u4e4b\u540e\uff0c\u8fd9\u4e9b\u5a74\u513f\u7ec6\u80de\u4ecd\u7136\u975e\u5e38\u6d3b\u8dc3\uff0c\u4e00\u65e6\u6bcd\u4eb2\u7684\u8eab\u4f53\u51fa\u73b0\u75c7\u72b6\uff0c\u5b83\u4eec\u4f1a\u8fc5\u901f\u96c6\u7ed3\uff0c\u51fa\u73b0\u5728\u67d3\u75c5\u7684\u5668\u5b98\u548c\u7ec4\u7ec7\u9644\u4ef6\uff0c\u53d8\u8eab\u5b8c\u7f8e\u7684\u6cbb\u6108\u7ec6\u80de\u540e\u53bb\u62b5\u6297\u75be\u75c5\u3002\u5728\u8fd9\u91cc\uff0c\u80da\u80ce\u7ec6\u80de\u626e\u6f14\u7684\u662f\u6bcd\u4eb2\u7ec8\u751f\u7684“\u5b88\u62a4\u8005\u548c\u4fdd\u9556”\u3002\u8fd9\u4e2a\u63a8\u6d4b\u4e0e\u4e2d\u56fd\u4f20\u7edf\u89c2\u70b9\uff1a\u751f\u5b50\u53bb\u75c5\uff0c\u6709\u5f02\u66f2\u540c\u5de5\u4e4b\u5999\u3002<\/p>\n

\n\t\u3000\u3000\u6bd4\u5b89\u5947\u7684\u5927\u80c6\u60f3\u6cd5\u5f15\u53d1\u4e86\u6bcd\u4f53\u4e0e\u5a74\u513f\u4e4b\u95f4\u5173\u7cfb\u7684\u521b\u65b0\u5f0f\u8868\u8ff0\u3002\u4f20\u7edf\u610f\u4e49\u4e0a\uff0c\u6bcd\u5a74\u5173\u7cfb\u662f\u5355\u5411\u7684\uff0c\u6bcd\u4eb2\u5728\u5b55\u671f\u6444\u5165\u591a\u9879\u8425\u517b\u7269\u8d28\uff0c\u901a\u8fc7\u8840\u6db2\u548c\u8110\u5e26\u5c06\u8425\u517b\u7269\u8d28\u8f93\u9001\u7ed9\u5a74\u513f\u3002\u4f46\u8fd9\u4ec5\u4ec5\u662f\u4e8b\u7269\u7684\u4e00\u9762\u3002\u6bd4\u5b89\u5947\u8bf4\uff1a“\u8110\u5e26\u662f\u53cc\u5411\u9ad8\u901f\u516c\u8def\uff0c\u8fd9\u79cd\u8425\u517b\u8865\u7ed9\u7684\u65b9\u5f0f\u8d70\u7684\u662f\u53cc\u5411\u8f66\u9053\u3002\u5728\u6000\u5b55\u521d\u671f\uff0c\u80da\u80ce\u5c31\u5f00\u59cb\u5411\u6bcd\u4f53\u91ca\u653e\u7ec6\u80de\uff0c\u6bcd\u4f53\u5219\u5c06\u8fd9\u4e9b\u5b9d\u8d35\u7684\u751f\u547d\u4e4b\u6e90\u50a8\u5b58\u8d77\u6765\uff0c\u7559\u7ed9\u5907\u7528\u4e4b\u9700\u3002\u5c31\u8c61\u6211\u4eec\u5e73\u65f6\u7528\u7684\u50a8\u94b1\u7f50\u4e00\u6837\uff0c\u6211\u4eec\u653e\u5165\u4e00\u4e9b\u5c0f\u5c0f\u7684\u786c\u5e01\uff0c\u7559\u5f85\u6700\u6025\u9700\u7684\u65f6\u5019\u4f7f\u7528\u3002”<\/p>\n

\n\t\u3000\u3000\u901a\u8fc7\u8fd9\u4e09\u4e2a\u6545\u4e8b\uff0c\u6211\u4eec\u53ef\u4ee5\u770b\u5230\uff0c\u5728\u79d1\u5b66\u5bb6\u7684\u52aa\u529b\u4e0b\uff0c\u4eba\u7c7b\u5df2\u7ecf\u80fd\u591f\u62e5\u6709\u6539\u53d8\u57fa\u56e0\u7ec4\u5408\u7684\u6f5c\u80fd\u3002\u901a\u8fc7\u57fa\u56e0\u4fee\u8865\u548c\u7f16\u8f91\u6280\u672f\u3002\u4eba\u7c7b\u5728\u6cbb\u7597\u75be\u75c5\u7684\u8fdb\u7a0b\u4e2d\uff0c\u53ef\u4ee5\u4f7f\u5065\u5eb7\u57fa\u56e0\u626e\u6f14“\u4fe1\u4f7f”\u3001“\u6740\u624b”\u3001“\u4fdd\u9556”\u7b49\u591a\u79cd\u89d2\u8272\u3002\u4e0e\u6b64\u540c\u65f6\uff0c\u5728\u57fa\u56e0\u6d4b\u5e8f\u6280\u672f\u4e0d\u65ad\u5b8c\u5584\u3001\u6210\u672c\u4e0d\u65ad\u964d\u4f4e\u7684\u5927\u80cc\u666f\u4e0b\uff0c\u57fa\u56e0\u91cd\u7ec4\u4ee5\u6cbb\u7597\u75be\u75c5\u7684\u624b\u6bb5\u8ddd\u79bb\u4e34\u5e8a\u5e94\u7528\u5df2\u7ecf\u8d8a\u6765\u8d8a\u8fd1\u3002<\/p>\n

\n\t\u3000\u3000\u53ef\u4ee5\u9884\u89c1\uff0c\u5728\u8fd9\u4e09\u4e2a\u6545\u4e8b\u7684\u9ad8\u6f6e\u9636\u6bb5\uff0c\u5fc5\u5c06\u662f\u57fa\u56e0\u6cbb\u7597\u624b\u6bb5\u9886\u57df\u5185\u7684\u4e13\u5229\u5927\u6218\u3002\u636e\u6089\uff0c\u7b2c\u4e8c\u4e2a\u6545\u4e8b\u4e2d\u7684\u4e3b\u89d2—-\u5bbe\u897f\u6cd5\u5c3c\u4e9a\u5927\u5b66\u5df2\u7ecf\u5c06\u5d4c\u5408\u6297\u539f\u53d7\u4f53\uff08Chimeric antigen receptor\uff09\uff0c\u5373\u52a0\u5de5T\u7ec6\u80de\u7684\u4e13\u5229\u6280\u672f\u6388\u4e88\u4e86\u745e\u58eb\u8bfa\u534e\u5236\u836f\u3002\u800c\u8fd9\u4e00\u5bf9\u5f3a\u5f3a\u7ec4\u5408\u9762\u4e34\u7684\u5bf9\u624b\u5305\u62ec\u7ebd\u7ea6\u7eaa\u5ff5\u65af\u9686\u51ef\u7279\u7433\u764c\u75c7\u4e2d\u5fc3\u7684\u5927\u4e1c\u5bb6\u6731\u8bfa\u6cbb\u7597\uff08JUNO THERAPEUTIC\uff09\u7b49\u9887\u5177\u5b9e\u529b\u7684\u8d22\u56e2\uff0c\u53cc\u65b9\u5df2\u7ecf\u5f00\u59cb\u51c6\u5907\u5728\u76f8\u5173\u7684\u5173\u952e\u7814\u7a76\u9886\u57df\u901a\u8fc7\u6cd5\u5f8b\u624b\u6bb5\u8bbe\u7acb\u4e13\u5229\u58c1\u5792\u3002\u800c\u5728\u7b2c\u4e09\u4e2a\u6545\u4e8b\u4e2d\uff0c\u6bd4\u5b89\u5947\u535a\u58eb\u6240\u62c5\u4efb\u987e\u95ee\u7684VERINATA\u516c\u53f8\u88ab\u73af\u7403\u77e5\u540d\u7684\u57fa\u56e0\u6d4b\u5e8f\u516c\u53f8ILLUMINA\u6536\u8d2d\u540e\uff0c\u4e5f\u5148\u540e\u4e0e\u4e3b\u8981\u7ade\u4e89\u5bf9\u624b\u5c55\u5f00\u4e86\u4e00\u7cfb\u5217\u7684\u4e13\u5229\u8bc9\u8bbc\u3002\u8fd9\u4e00\u7cfb\u5217\u6fc0\u70c8\u7684\u5bf9\u6297\uff0c\u8db3\u4ee5\u663e\u793a\u51fa\u8d44\u672c\u5bf9\u4e8e\u8fd9\u4e2a\u9886\u57df\u7684\u5173\u6ce8\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"

\u81ea2\u6708\u4ee5\u6765\uff0c\u7f8e\u56fd\u751f\u7269\u5236\u836f\u754c\u6380\u8d77\u4e86\u4e00\u80a1IPO\u72c2\u6f6e\uff0c\u603b\u5171\u67098\u5bb6\u521b\u65b0\u578b\u516c\u53f8\u643a\u5e26\u7740\u672a\u7ecf\u5145\u5206\u4e34\u5e8a\u9a8c\u8bc1\u7684\u6280\u672f\u5728\u8d44\u672c\u5e02\u573a\u4e0a\u5174 […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[411],"tags":[],"class_list":["post-6588","post","type-post","status-publish","format-standard","hentry","category-411"],"_links":{"self":[{"href":"https:\/\/az.c.adneti.net\/cn\/index.php?rest_route=\/wp\/v2\/posts\/6588"}],"collection":[{"href":"https:\/\/az.c.adneti.net\/cn\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/az.c.adneti.net\/cn\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/az.c.adneti.net\/cn\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/az.c.adneti.net\/cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=6588"}],"version-history":[{"count":1,"href":"https:\/\/az.c.adneti.net\/cn\/index.php?rest_route=\/wp\/v2\/posts\/6588\/revisions"}],"predecessor-version":[{"id":31580,"href":"https:\/\/az.c.adneti.net\/cn\/index.php?rest_route=\/wp\/v2\/posts\/6588\/revisions\/31580"}],"wp:attachment":[{"href":"https:\/\/az.c.adneti.net\/cn\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=6588"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/az.c.adneti.net\/cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=6588"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/az.c.adneti.net\/cn\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=6588"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}